Collaboration, innovation and knowledge sharing are key to the business model of Synectix
The following is a list of selected publications by the scientists involved in Synectix Pharmaceutical Solutions Ltd. Re-prints of any articles can be ordered by contacting us via e-mail with the title of the requested journal.
Analytical Sciences
Books
- Gaisford S, O'Neill MAA. Pharmaceutical Isothermal Calorimetry; 2006, Informa Healthcare (New York) ISBN 0-8493-3155-2
Book chapters
- Gaisford S. High-sensitivity differential scanning calorimetry. In; Thermal analysis of Pharmaceuticals, Craig DQM, Reading M (Eds), 2007, Marcel Dekker (Boca Raton) ISBN 0-8247-5814-1
- Gaisford S, The use of microcalorimetry for stress testing.
In; Pharmaceutical stress testing: Predicting drug degradation, Baertschi SW (Ed), 2006, Marcel Dekker (Boca Raton) ISBN 0-8247-4021-1
Journal Articles
- O'Neill MAA, Beezer AE, Tetteh J, Gaisford S, Dhuna M. Application of chemometric analysis to complexity in isothermal calorimetric data. J. Phys.
Chem. B., 2007, DOI: 10.1021/jp0700985. - Gaisford S, Ramos R. Calorimetry for amorphous content quantification. Eur.
Pharm. Rev., 2007, 12(3):46-52. - Gaisford S, O'Neill MAA. Calorimetry for polymorph detection. Eur. Pharm.
Rev., 2007, 12(2):70-74. - Dhuna M, Beezer AE, Morris AC, Gaisford S, OčNeill MAA, Hadgraft J, Connor JA, Clapham D, Frost J. Development of an isothermal heat-conduction photocalorimeter. Rev. Sci. Inst., 2007, DOI: 10.1063/1.2670220.
- Gaisford S, O'Neill MAA, Thompson L, Chan K-L. Shelf-life prediction of intraveneous busulfan by isothermal calorimetry. Hosp. Pharm., 2006, 13:295-298.
- O'Neill MAA, Gaisford S, Beezer AE, Skaria CV, Sears P. A comparison of the performance of calorimeters: Application of a test and reference reaction. J. Therm. Anal. Cal., 2006, 84:301-306.
- Hay FR, O'Neill MAA, Beezer AE, Gaisford S. Isothermal micro-calorimetry: a tool to predict seed longevity? Seed Sci Res., 2006, 16:89-96.
- Finnin BA, O'Neill MAA, Gaisford S, Beezer AE, Hadgraft J, Sears P. Performance validation of step-isothermal calorimeters: Application of a test and reference reaction. J. Therm. Anal. Cal., 2006, 83:331-334.
- Burgess SE, O'Neill MAA, Beezer AE, Hadgraft J, Gaisford S. Thermodynamics of membrane transport and implications for dermal delivery. J. Drug Del. Sci. Tech., 2005, 15:325-327.
- Gaisford S. Stability assessment of pharmaceuticals and biopharmaceuticals by isothermal microcalorimetry. Curr. Pharm. Biotech., 2005, 6:181-191.
- Royall PG, Gaisford S. Application of solution calorimetry in pharmaceutical and biopharmaceutical research. Curr. Pharm. Biotech., 2005, 6:215-222.
- Gaisford S, Royall PG, Greig DGT. Solution calorimetry as a tool to study the neutralizing capacity of magnesium trisilicate mixture BP and its components. Thermochimica Acta, 2004, 417:217-221.
Formulation Research
- Ibekwe V.C., Liu F., Fadda H.M. Khela M.K., Evans D.F., Parsons G.E. and Basit A.W. An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans. Journal of Pharmaceutical Sciences 95, 2760-2766 (2006)
- Schulze J.D.R., Ashiru D.A.I., Khela M.K., Evans D.F., Patel R., Parsons G.E., Coffin M.D. and Basit A.W. Impact of formulation excipients on gastrointestinal transit in humans. Journal of Pharmacy and Pharmacology 58, 821-825 (2006)
- Ibekwe V.C., Fadda H.M., Parsons G.E. and Basit A.W. A comparative in vitro assessment of the drug release performance of pH responsive polymers for ileo-colonic delivery. International Journal of Pharmaceutics 308, 52-60 (2006)
- Fadda H.M. and Basit A.W. Gastrointestinal tract: obstacles or opportunities in drug targeting? Pharma 1(1), 52-59 (2005)
- Mwesigwa E., and Basit A.W. The hygroscopicity of moisture barrier film coatings. Drug Development and Industrial Pharmacy 31, 959-968 (2005)
- Basit A.W. Advances in colonic drug delivery. Drugs 65, 1991-2007 (2005)
Kendall R.A., Murdan S. and Basit A.W. Modified-release microparticles for oral drug delivery. Drug Delivery Technology 5(8), 76-80 (2005) - Wilson P.J. and Basit A.W. Exploiting gastrointestinal bacteria to target drugs to the colon: an in vitro study using amylose coated tablets. International Journal of Pharmaceutics 300, 89-94 (2005)
- Schulze J.D.R., Parsons G.E., Peters E.E., Staton J.S., Coffin M.D. and Basit A.W.Excipient effects on gastrointestinal transit and drug absorption in beagle dogs. International Journal of Pharmaceutics 300, 67-75 (2005).
- Fadda H.M. and Basit A.W. Dissolution of pH responsive formulations in media resembling intestinal fluids: bicarbonate versus phosphate buffers. Journal of Drug Delivery Science and Technology 15, 273-279 (2005).
- Basit A.W., Kendall R.A. and Murdan S. Method of producing microparticles. WO 2005/070391 (2005)
- Basit, A.W. Podczeck F., Newton J.M., Waddington W.A., Ell P.J. and Lacey L.F. The use of formulation technology to asses regional gastrointestinal drug absorption in humans. European Journal of Pharmaceutical Sciences 21, 179-189 (2004).
- Siew L.F., Man S.M., Newton J.M. and Basit A.W.Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro. International Journal of Pharmaceutics 273, 129-134 (2004).
- Schulze J.D.R., Waddington W.A., Ell P.J., Parsons G.E., Coffin M.D. and Basit A.W. Concentration-dependent effects of polyethylene glycol 400 on gastrointestinal transit and drug absorption. Pharmaceutical Research 20, 1984-1988 (2003).
- Palmer R.M.J., Newton J.M., Basit A.W. and Bloor J.R. Colonic release composition. WO 03/068196 (2003)
- Tuleu, C., Basit, A.W., Waddington, W.A., Ell, P.J., Newton, J.M. Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose coated hydroxypropylmethylcellulose capsules. Alimentary Pharmacology and Therapeutics 16, 1771-1779 (2002).
- Basit A.W., Podczeck F., Newton J.M., Waddington W.A., Ell P.J. and Lacey L.F. Influence of polyethylene glycol 400 on the gastrointestinal absorption of ranitidine. Pharmaceutical Research 19, 1365-1371 (2002).
- Basit, A.W. and Lacey, L.F. Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. International Journal of Pharmaceutics 237, 23-33 (2002).
- Basit, A.W., Lacey, L.F. Colonic metabolism of ranitidine: Implications for its delivery and absorption. International Journal of Pharmaceutics 227, 157-165 (2001).
- Basit, A.W., Newton, J.M., Short, M.D., Waddington, W.A., Ell, P.J., Lacey, L.F. The effect of polyethylene glycol 400 on gastrointestinal transit: Implications for the formulation of poorly water-soluble drugs. Pharmaceutical Research 18, 1146-1150 (2001).
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